一种含磷酸肌醇3-激酶抑制剂及拓扑酶抑制剂的抗癌组合物

Anticancer composition containing phosphoinositide-3-kinase inhibitor and topomerase inhibitor

Abstract

一种含磷酸肌醇3-激酶抑制剂(PI3Ki)和/或拓扑酶抑制剂的抗癌组合物为缓释注射剂,由缓释微球和溶媒组成。其中缓释微球由PI3Ki和/或拓扑酶抑制剂和缓释辅料组成,溶媒为普通溶媒或含助悬剂的特殊溶媒。助悬剂的黏度为100cp-3000cp(20℃-30℃时),选自羧甲基纤维素钠等;缓释辅料选自p(LAEG-EOP)、p(DAPG-EOP)、p(BHET-EOP/TC)、p(BHET-EOP/TC)、p(BHDPT-EOP/TC)、p(BHDPT-EOP/TC)、p(CHDM-HOP)或p(CHDM-EOP)等聚磷酸酯共聚物或聚磷酸酯与聚乳酸、聚苯丙生、双脂肪酸与癸二酸共聚物、聚(芥酸二聚体-癸二酸)或聚(富马酸-癸二酸)的共聚或共混物;抗癌组合物还制成缓释植入剂,瘤内或瘤周注射或放置可维持有效药物浓度达40天以上,还能够明显降低药物的全身反应,并选择性地增强放化疗等非手术疗法的治疗效果。
The slow released anticancer injection containing both phosphoinositide-3-kinase inhibitor and/or topomerase innhibitor consists of slow released microsphere and solvent. The slow released microsphere includes effective anticancer component and slow releasing supplementary material, and the solvent is common solvent or special solvent containing suspending agent. The suspending agent is sodium carboxymethyl cellulose, etc. and has viscosity of 100-3000 cp at 20-30 deg.c. The slow releasing supplementary material is p(LAEG-EOP), p(DAPG-EOP), p(BHET-EOP/TC), p( BHET-EOP/TC), p(BHDPT-EOP/TC), p(BHDPT-EOP/TC), p(CHDM-HOP), p(CHDM-EOP) , etc. The anticancer composition may be also prepared into slow released implanting agent for use alone or together with chemotherapeutic and/or radiotherapeutic medicine to strengthen the treatment effect.

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